Je kunt ook een 16x16 meest perfect magisch vierkant maken met vier (4x4) Sudoku-patronen. Zie voor meer uitleg het 4x4 (Sudoku) en het 8x8 (Sudoku) magische vierkant.
Neem 4x getal uit het 1e patroon +1 + 1x getal uit het 2e patroon
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+16x getal uit het 3e (vaste) patroon + 64x getal uit het 4e (vaste) patroon
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